Stevens Johnson Syndrome Symptoms | Medical Algorithm

Evaluation

HLA Screening to Identify Asian Patient at Risk for Carbamazepine-Associated Stevens-Johnson Syndrome

MyLikes

MyPaths

Info

Are you evaluating a patient prior to starting carbamazepine therapy?

Yes No

Does the patient have an Asian ancestry?

Yes No

Does the patient have HLA-B*1502?

Select

Does the patient have HLA-B*0702?

Select

Results

HLA Screening to Identify Asian Patient at Risk for Carbamazepine-Associated Stevens-Johnson Syndrome

MyLikes

MyPaths

Info

Results

Data complete?

Evaluation appropriate?

Is the patient at increased risk for the Stevens Johnson Syndrome after starting carbamazepine therapy?

The risk of a severe hypersensitivity reaction to carbamazepine therapy

Caution: A qualified health practitioner should verify all results. Keep patient data confidential and comply with all legal requirements.

Please visit our website Medicalalgorithms.com for Interpretation and Description and further algorithms you may want to consider in the next steps of your evaluation. All information should be verified by a qualified health professional, and all use is subject to The Medical Algorithms Terms and Conditions. Copyright © The Medical Algorithms Company Limited

Consider These Analytics

Diagnosis

Risk Factors

H Pylori Treatment Failure Score
Predict Severe Toxicity Associated with Fluorouracil (5-FU) Therapy
Identifying Patients at Risk for Irinotecan (Camptosar) Myelotoxicity Based on UGT1A1 Genotype
Reduced Effectiveness of Tamoxifen Therapy Secondary to Altered Biotransformation

Laboratory Tests

Determining Isoniazid Acetylation Phenotype Based on Measurement of Urinary Isoniazid and Acetylisoniazid
ABCB1 Polymorphism Test Prior to Therapy with Docetaxel or Irinotecan

Other Testing

Methotrexate Toxicity & MTHFR (Methelenetetrahydrofolate Reductase) C677T Polymorphism
Impact of CYP2C19 Phenotype on Clopidogrel Response

Criteria For Diagnosis

Warfarin for Polymorphism in Cytochrome P450 (CYP) CYP2C9 | Medical Algorithm

Severity, Prognosis, Stage

Predict Severe Toxicity Associated with Fluorouracil (5-FU) Therapy

Therapy

Selection

H Pylori Treatment Failure Score
Pharmacogenetic Model for Predicting Efficacy of Methotrexate Monotherapy in Patient with Rheumatoid Arthritis
Identifying Patients at Risk for Irinotecan (Camptosar) Myelotoxicity Based on UGT1A1 Genotype
Warfarin for Polymorphism in Cytochrome P450 (CYP) CYP2C9 | Medical Algorithm
Reduced Effectiveness of Tamoxifen Therapy Secondary to Altered Biotransformation
Impact of CYP2C19 Phenotype on Clopidogrel Response
Effect of Polymorphism in Cytochrome P450 (CYP) CYP2D6 on Metabolism of Oxycodone

Pharmacogenetics

H Pylori Treatment Failure Score
Pharmacogenetic Model for Predicting Efficacy of Methotrexate Monotherapy in Patient with Rheumatoid Arthritis
Effect of Polymorphism in Cytochrome P450 (CYP) CYP2D6 on Metabolism of Oxycodone
ABCB1 Polymorphism Test Prior to Therapy with Docetaxel or Irinotecan

Dosage Adjustments

Efavirenz Dose Reduction in HIV-1 Infected Patient Based on CYP2B6 Genotype

Monitoring

Response To Therapy

Pharmacogenetic Model for Predicting Efficacy of Methotrexate Monotherapy in Patient with Rheumatoid Arthritis
Reduced Effectiveness of Tamoxifen Therapy Secondary to Altered Biotransformation
Impact of CYP2C19 Phenotype on Clopidogrel Response

Adverse Effects

Efavirenz Dose Reduction in HIV-1 Infected Patient Based on CYP2B6 Genotype
Methotrexate Toxicity & MTHFR (Methelenetetrahydrofolate Reductase) C677T Polymorphism

Share this Algorithm

Facebook

Twitter

E-mail

Algorithm Information

HLA Screening to Identify Asian Patient at Risk for Carbamazepine-Associated Stevens-Johnson Syndrome

MyLikes

MyPaths

Purpose:

To identify a patient who may be at increased risk for carbamazepine-associated Stevens Johnson Syndrome (SJS).

Specialty

Toxicology
Emergency Medicine
Critical Care
Genetics

Objective

Risk factors
Selection
Adverse effects

ICD-10

L51.1

References

Interpretation and Description

Share this Algorithm

Facebook

Twitter

E-mail